LIST OF APPROVED PROJECTS

  1. Phase 1 National Precision Medicine Programme

    NTU John Chambers, Marie Loh, Joanne Ngeow; GIS Patrick Tan; NUH & NUS Tai E Shyong; SICS Neerja Karnani; NUS Sim Xueling

  2. Asian Skin Microbiome Programme

    SRIS Thomas Dawson, John Common; GIS Niranjan Nagarajan; NTU John Chambers

  3. The associations of adiposity with ethnic difference in the metabolic phenotypes of South East Asians, and related investigations

    NTU Theresia Mina, John Chambers, Joanne Ngeow, Marie Loh; NHGP Lee Eng Sing; IMH Jimmy Lee; ICL Elio Riboli, Paul Elliott, TTSH Gervais Wansaicheong, Rinkoo Dalan

  4. The associations of general cognition with metabolic syndrome severity in multi-ethnic South East Asia, and related investigations

    NTU Theresia Mina, John Chambers, Konstadina Griva, Joanne Ngeow; IMH Jimmy Lee; ICL Elio Riboli, Paul Elliott; NHGP Lee Sng Sing

  5. Investigation of Mechanisms Underlying Obesity Amongst Chinese, Malays and Indians in Singapore

    KTPH Dr Benjamin Lam (KTPH); NTU John Chambers, Marie Loh, Theresia Mina; GIS Niranjan Nagararajan

  6. To determine the degree of overlap of individuals between the National Precision Medicine Phase I research cohort (SG10K_Health), HPB's programmes and MOH Clinical Data through linkage of tokenised NRIC numbers.

    HPB Karen Cheong, Lim Kim Tee, Albert Goh

  7. Multimorbidity and pharmacogenomics

    NHGP Lee Eng Sing, Tricia Chang; NTU John Chambers, Marie Loh; NHGP Kee Kok Wai, Sabrina Lee, Chow Zi Siong

  8. Development of an Osteoporosis Risk Index

    NHGP Lee Eng Sing (NHGP); KKH Ang Seng Bin; Duke-NUS Satvinder Dhaliwal, Xia Junyan; TTSH Gervais Wansaicheong; NTU Marie Loh, Theresia Mina; NHGP Tricia Chang, Kee Kok Wai

  9. A collaboration for metabolomic profiling of HELIOS study participants by mass spectroscopy

    NTU John Chambers, Marie Loh, Guan Xueli, Sarah Langley; TTSH Rinkoo Dalan; Metabolon Gregory Michelotti

  10. Asian Immune Diversity Atlas (AIDA)

    GIS Shyam Prabhakar; RIKEN Japan Jay Shin; Samsung Genome Institute, Korea Woong-Yang Park; National Institute of Biomedical Genomics, India; Mahidol University, Thailand Partha Majumder Varodom Charoensawan; King Abdullah University of Science and Technology, Saudi Arabia Abdullah Khamis; Russian Academy of Science Yulia Medvedeva; NTU John Chambers, Marie Loh

  11. Trusted Research/ Real world-data Utilisation and Sharing Tech (“TRUST”) Platform Phase 1 development – Data on-boarding preparation (de-identification)

    NTU John Chambers, Marie Loh, Joanne Ngeow; GIS Patrick Tan; NUS, NUH Tai E Shyong; NUS Sim Xueling; Duke-NUS Saumya Jamuar, Lim Weng Khong; HPB Annie Ling, Karen Cheong; MOHT Koh Mingshi, Low Pinyan

  12. Assessing in type 2 diabetes mellitus associated risk factors for cognitive impairment in European and multi-ethnic Singaporean populations

    NTU Sarah Langley; IMH Jimmy Lee

  13. Exploring genetics and non-genetics relationships of methylation in a multi-ethnic Singapore population

    NTU Marie Loh, John Chambers; NSC Yew Yik Weng, University of Melbourne Lachlan Coin

  14. Defining the healthy Asian skin microbiome and establishing corresponding in vitro models for material development (an industry collaboration with the Asian Skin Microbiome Programme)

    SRIS Stephen Wearne, John Common, Thomas Dawson; GIS Niranjan Nagarajan (GIS); NTU Yew Yik Weng; Firmenich Monica Bandera

  15. Assessing the association between atopic dermatitis (AD) and psychological co-morbidities in a multi-ethnic South East Asian population

    NSC Yew Yik Weng (NSC); NTU Marie Loh

  16. Investigating the effect of adiposity on serum proteomic profile in a general population cohort

    NSC Yew Yik Weng, Steven Thng; NTU Marie Loh, John Chambers, Guan Xueli; SRIS John Common

  17. NPM RAPTOR Workbench Internal Development

    GIS Nicolas Bertin, Maxime Hebrard, Roberto Tirado Magallanes

  18. Longitudinal clinical, genetic and imaging study of prodromal Parkinson's Disease in Singapore

    NNI Xu Zheyu, Louis Tan, Au Wing Lok, Tay Kay Yaw, Ng Su Lyn Adeline, Neo Xiumin Shermyn, Manharlal Prakash Kumar, Hameed Shahul, Ratnagopal Pavanni, Tan Eng King; SGH Chan Ling Ling, Leow Leong Chai; SERI Ecosse Lamoureux

  19. Prevalence and trajectories of mental distress during the COVID-19 pandemic in Singapore

    NTU Konstadina Griva, Theresia Mina, Tan Yit Kiat, Kevin; NCID Alexius S. E. Soh, Mark Chen

  20. Understanding the role of diet in influencing cardiometabolic health and metabolome in the South-East Asian population

    NTU Dorrain Low, Theresia Mina, John Chambers, Marie Loh, Nilanjana Sadhu

  21. Prevalence of Chronic Kidney Disease (CKD) in a multi-ethnic Asian population in Singapore and its associated risk factors

    TTSH Yeo See Cheng, Weng Wanting, Ooi Xi Yan; NTU John Chambers, Marie Loh

  22. AIDA Phase 2: Genetics, gender & geography (An update to application No. 10)

    GIS Shyam Prabhakar; NTU John Chambers, Marie Loh; GIS Jay Shin; Samsung Genome Institute, Korea Woong-Yang Park; National Institute of Biomedical Genomics, India Partha Majumder; Mahidol University, Thailand Varodom Charoensawan; King Abdullah University of Science and Technology, Saudi Arabia Abdullah Khamis; RIKEN, Osaka University Yukinori Okada Ponpan Matangkasombut-Choopong; Services Institute of Medical Sciences, Pakistan Khadija Irfan Khawaja; University of Kelaniya Anuradhani Kasturiratne; Seoul National University Murim Choi; RIKEN Japan Chung Chau Hon, Kazuyoshi Ishigaki; NUS Boxiang Liu; KAIST Youngseok Park, Jongeun Park; Samsung Genome Institute and Sungkyunkwan University Hong-Hee Won

  23. Hypertension stratification with renin and aldosterone in three Singapore ethnic groups

    CGH Troy Puar, Daryl Hee, Tan Yi Ting, Zhang Meifen; NUHS Roger Foo; NTU John Chambers

  24. Linkage of HELIOS data for technical evaluation and training

    NTU John Chambers, Marie Loh, Joanne Ngeow, Nilanjana Sadhu; PRECISE Patrick Tan; NUS Sim Xueling; Duke-NUS Cheng Ching Yu; NHCS Yeo Khung Keong; GIS Liu Jianjun; BII Sebastian Maurer-Stroh; NHG Lim Tock Han; NHGP Lee Eng Sing; IMH Jimmy Lee, Max Lam

  25. Burden of skin diseases and itch in an adult general population cohort

    NTU Marie Loh; NSC Yew Yik Weng

  26. Comparison of various diagnostic criteria for atopic dermatitis (AD) in a adult general population cohort

    NTU Marie Loh; NSC Yew Yik Weng

  27. Cognitive Epidemiology in UK Biobank and HELIOS/SG100K

    IMH Max Lam, Jimmy Lee; NTU John Chambers, Marie Loh, Theresia Mina

  28. Development of cardiovascular disease (CVD) and Type 2 diabetes (T2D) risk models using subclinical outcomes from the combination of wearable, molecular and phenotypic data in HELIOS and Health Promotion Board's (HPB) Health Insights Singapore (hiSG) Study

    NTU Marie Loh, Xie Wubin, Wang Xiaoyan, Ng Hong Kiat, John Chambers; HPN Karen Cheong, Chelsea Chang, Daniel Chander, Janelle Chia

  29. Osteoporosis Retina Prediction: ORION

    NHGP Tan Shu Yun, Fong Qi Wei; TTSH Kelvin Li , NTU Lee Eng Sing, Kwoh Chee Keong, Jeremy Lew Kai Wei; NHG Lim Tock Han

  30. Cognitive functioning and COVID 19 – a matched control analysis

    NTU Konstadina Griva; NCID Barnaby Edward Young; NNI Nicole Keong Chwee Har; IMH Jimmy Lee; TTSH Puah Ser Hon (TTSH)

  31. Reference ranges of body composition and bone mineral density by dual-energy X-ray absorptiometry in multi-ethnic Singapore adults: the Health for Life in Singapore (HELIOS) Study

    NTU Wang Xiaoyan, Theresia Mina, Wubin Xie, John Chambers

  32. INDEPTHOS: INvestigating the Diagnostic, Epidemiologic and Predictive measures that define OsteoSarcopenia

    TTSH Michael Yam; NHGP Lee Eng Sing; TTSH Alvin Tan Wai Kit

  33. Dissecting the context-specificity of genetic immune regulation in plasmacytoid dendritic cells

    Helmholtz Munich Sarah Kim-Hellmuth; NTU John Chambers

  34. Hearing impairment, disability, handicap and cognitive decline in the Singapore population
    (Ref: HELIOS-EDC2/18005) (NTU IRB-2016-11-030)

    TTSH Angela Chow; IMH Jimmy Lee; NTU John Chambers; ENT Clinic Ho Eu Chin

  35. Asian Skin Microbiome Programme 2.0 (ASMP 2.0)

    A*SRL John Common, James Chan, Sze Han Lee, Thomas Dawson; GIS Niranjan Nagarajan; NTU Marie Loh, John Chambers

  36. DIET-MAPS: Deciphering the Interplay of Dietary Patterns, Microbiome, and Asian Populations: Unveiling Inflammatory Connections

    NTU Sunny Wong, Yusuf Ali, Marie Loh, Kazuyuki Kasahara, Kajal Agrawal, Chung Chi Kong Arthur, Jason Kang Xing; SICS Jeannie Tay (SICS), Marie Loh (NTU),

  37. Understanding how human metabolome and gut microbiome variation are influenced by lifestyle and genetic factors

    NTU Dorrain Low, Theresia Mina, Nilanjana Sadhu, Pritesh Jain; KTPH Benjamin Lam; GIS Jonathan Teo Jin Yuan

  38. This is a collective study effort consisting of 4 groups from the Tan Tock Seng Eye Department.
    a) Application of Artificial Intelligence and deep learning for clinical application in Ophthalmology
    b) Deep phenotyping of drusen and its association with systemic metabolic biomarkers
    c) Exploring choroidal angiostructure by choroidal vascularity index in a large population-based study - HELIOS (Health for Life in Singapore)
    d) Ocular and Systemic Associations of Glaucoma in the HELIOS (Health for Life in Singapore) Population Cohort – A Pilot Study
    e) Evaluating the prevalence and genetic spectrum associated with eye disorders in a Singaporean (HELIOS) population cohort
    f) Resolving Variants of Unknown Significance In Ocular genetics : Leveraging real world data

    TTSH Kelvin Li, Lim Tock Han, Ngo Wei Kiong, Bryan Ang, Rupesh Agrawal, Wei Xin; NTU John Chambers, Joanne Ngeow

  39. The role of eating behaviour in cardiometabolic health in Asian population

    NTU Theresia Mina, John Chambers, Marie Loh, Max Lam, Dorrain Loq; IMH Jimmy Lee

  40. Validation of Spirometry Reference Equations in a Multi-ethnic Adult Population Study.

    TTSH Tan Geak Poh (TTSH); NTU Sanjay Chotirmall; NHG John Abisheganaden, Meng Fanwen

  41. Epigenome-wide association study of methylation alterations linked to carotid intima-media thickness in a multi-Asian general population cohort

    NTU Marie Loh, Konstanze Tan; TTSH Rinkoo Dalan

  42. Ultra-processed food consumption and cardiometabolic disease risk in the multi-ethnic Singaporean population

    Cambridge Lee Jia Yi, Nita Forouhi, Fumiaki Imamura; NTU John Chambers, Theresia Mina, Dorrain Low

  43. Evaluation of whole-genome sequencing data performed on MGI T10 platform

    GIS Liu Jianjun, Rajkumar Dorajoo, Sim Kar Seng, Shih Chih Chuan; NTU Marie Loh

  44. Establishing clinical significance of LPa levels in general population of Singapore

    CGH Loh Wann Jia; NTU John Chambers; TTSH Rinkoo Dalan

  45. A comparison of adiposity quantification measured by Bioelectrical Impedance (BIA) and Dual Energy X-Ray Absorptiometry (DEXA) in the Asian population

    NTU Wang Xiaoyan, Theresia Mina, John Chambers

  46. Wearables data and other non-invasive measurements for early cardiometabolic risk stratification

    LKCMedicine Crystal Tang, Marie Loh, John Chambers

  47. PRECISE-SG100K Flagship Proteomics Project

    NTU John Chambers, Nilanjana Sadhu, Akash Bahai; NUS Sim Xueling; SERI Cheng Ching-yu; Boehringer Ingelheim Ding Zhihao; Novo Nordisk Joanna Howson; Bayer Joerg Lippert; Alnylam Pharmaceuticals Luke Ward

  48. Cognitive performance in atopic dermatitis: Evaluating chronic immune–inflammatory and metabolic disruptions in a multi-ethnic Singaporean cohort through integrative multi-omics and interpretable machine learning

    NTU Vishnupriya Kannan, Marie Loh, Yew Yik Weng, Jimmy Lee

  49. HD4 – Health-driven design for cities

    LKCMedicine John Chambers, Theresia Mina, Marie Loh, Xiaoyan Wang, Dorrain Low, Jimmy Lee, Sabrina Wong, Cambridge Nita Forouhi, Nick Wareham, Soren Brage, Louise Foley, Jana Panter, NUS Xueling Sim

  50. Implementation and Evaluation of a Polygenic Risk Score (PRS) Intervention for The Improvement of Patient's Risk Perception, Self -Management, And Behavioural Change

    TTSH Rinkoo Dalan, Aloysius Chia, Goh Liuh Ling, Dana Chan

  51. Personalized healthcare using diagnostic stratification, genomics and artificial intelligence (part of the In-Cypher programme)

    NTU Theresia Mina, Xie Wubin, Keisuke Ejima, John Chambers, TTSH Rinkoo Dalan, Cambridge Anil Bharath, Nick Oliver

  52. A field-based study of HEATS: Heat Exposure AcTivity and Sleep

    NUS Jason Lee, Chua Yun Xuan, June Lo, Clayton Carl Miller, Pearl Tan, Wenhao Zhang, Shawn Tan, Toby Seah, Gabriel May, Clarence Hong, Audrey Florensia, Ahlem Dorgham, Berkeley Stefano Schiavon, Hui Zhang, Mario Frei, Xiaojun Fan, UoS Thomas Parkinson,

  53. Developing risk models for cancer associations

    NTU Joanne Ngeow, Sabrina Wong, GIS Rajkumar S/O Dorajoo, Cambridge Elio Riboli

  54. Optimizing Cardiovascular Risk Prediction Strategies for people with Familial Hypercholesterolemia

    KTPH Jeremy Hoe, Subramaniam Tavintharan, NTU John Chambers, Theresia Mina, Maria Loh, NUS Lim Weng Khong

  55. Pathogenic variants associated with dominantly inherited retinal degenerations display extreme phenotypic variance and variable penetrance

    SNEC Beau Fenner, Tan Tien-En, Gemmy Cheung, Duke NUS Lim Weng Khong, TTSH Ngo Wei Kiong

  56. ADEPT: Atopic DErmatitis research Program for patienTs

    NSC Yew Yik Weng, NTU Marie Loh, Franklin Zhong, A* SRL John Common, Koh Li Fang, Kenneth Lay, James Chan, Lee Sze Han, A*STAR BII Sebestian Maurer-Strob, Woo Xing Yi

  57. Menopause and Cognitive Function in Midlife Women: Insights from the HELIOS Cohort

    NTU Konstadina Griva, Theresia Mina, Parvethi Pazhaya, Akshanya Krishna, IMH Jimmy Lee, Menopause Alliance Singapore Dianne Tan, UHK Frederick Chan, UCL Aimme Speck

  58. The Impact on Population Health Arising from Alterations of the Gut Microbiome Associated with Bile Acid Homeostasis in the Development of Hepatocellular Carcinoma (HCC)

    NCC Pierce Chow,NTU Sunny Wong, Joanne Ngeow, Wang Yu Lan, IMCB Han Weiping, NUS / NUHS Koh Woon Puay,Mark Muthiah Pittsburg Yuan Jian Min, AMILI Jeremy Lim

  59. Genome-wide association studies of bone mineral density at multiple skeletal sites and its clinical relevance in multi-ethnic Asian adults

    NTU Wang Xiaoyan, Pritesh Rajesh Jain, Theresia Mina, John Chambers

  60. Circulating Trigonelline and Kidney Function: Insights into NAD+ - related metabolic pathways in a multi-ethnic Singapore cohort

    NTU Marie Loh, Ng Hong Kiat, Dayang Nurul Asyiqin Binte Mustafa, NUS Vincenzo Sorrentino, Nestlé Institute of Health Sciences Jerome Feige